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SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 42 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D improves heart health
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Study shows vitamin D benefits
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
8
Vitamin D3 offers cardiac protection
Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress.
Study highlights vitamin D3 benefits.
We examined how vitamin D3 could play a role in protecting the heart from damage caused by cisplatin, a chemotherapy drug. In our research, we worked with male Balb-c mice, dividing them into several groups to evaluate different treatment approaches. Some groups received vitamin D3 before or after cisplatin injection, while others acted as controls.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Read More
4
Vitamin D3 worsens heart dysfunction
Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes.
High relevance to heart health
We investigated how vitamin D3 treatment affects heart disease, particularly focusing on the connection between aortic calcification and cardiac dysfunction. In our study, C57BL/6 mice received daily doses of vitamin D for two weeks, allowing us to observe various factors such as arterial elasticity and cardiac health over an extended period.
As we analyzed the results, we found that vitamin D treatment led to significant aortic calcification and increased pulse propagation velocity. Unfortunately, rather than improving heart function, this treatment correlated with worsened cardiac performance and increased apoptosis, or programmed cell death, among heart cells.
By examining rat heart cells exposed to media from calcified vascular smooth muscle cells, we noticed a similar trend—these conditions caused apoptosis and altered the expression of genes crucial for heart function. Overall, our findings suggest that while vitamin D is often associated with health benefits, in this context, it accelerates cardiac dysfunction through mechanisms like inducing cell death in heart tissues.
These results offer critical insights into the potential dangers of elevated vitamin D levels, particularly in relation to heart health. They highlight the need for further research to better understand these effects and guide treatment strategies for those at risk of heart disease.
As we analyzed the results, we found that vitamin D treatment led to significant aortic calcification and increased pulse propagation velocity. Unfortunately, rather than improving heart function, this treatment correlated with worsened cardiac performance and increased apoptosis, or programmed cell death, among heart cells.
By examining rat heart cells exposed to media from calcified vascular smooth muscle cells, we noticed a similar trend—these conditions caused apoptosis and altered the expression of genes crucial for heart function. Overall, our findings suggest that while vitamin D is often associated with health benefits, in this context, it accelerates cardiac dysfunction through mechanisms like inducing cell death in heart tissues.
These results offer critical insights into the potential dangers of elevated vitamin D levels, particularly in relation to heart health. They highlight the need for further research to better understand these effects and guide treatment strategies for those at risk of heart disease.
Read More
Most Useful Reviews
9.5
Strong immunity support
One capsule a day ensures effective immunity against various viral diseases. My family, including my children, hasn't had a cold or any viral illness for years, aside from a mild runny nose that resolved quickly. With my thyroid condition, vitamin D3 is essential. Its deficiency is linked to heart disease and other autoimmune issues.
Read More
9.5
Eliminated symptoms
Prescribed for my heart disease, this supplement has proven effective. My night sweats and shortness of breath have disappeared, and I experienced no side effects. I may update later with more effects.
Read More
4.5
Vitamin D benefit
EXCELLENT VITAMIN D-3 from NOW. In spring 2019, I had a severe Vitamin D-3 deficiency which led to a dreadful condition called ONYCHOLYSIS OF NAILS. After two months of taking this vitamin D-3 as prescribed by my endocrinologist, I restored my Vitamin D levels completely and overcame ONYCHOLYSIS. Now, I take 2000 IU daily, as this vitamin is essential for everyone, especially pregnant women and during menopause.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
8
Vitamin D improves heart health
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Study shows vitamin D benefits
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
8
Vitamin D3 shows potential heart protection
Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D3 on doxorubicin-induced acute cardiotoxicity in rats.
Study details vitamin D3 usage
We explored the effects of vitamin D3 and paricalcitol on heart health, particularly in the context of doxorubicin-induced cardiotoxicity. In our study, we worked with male Wistar rats divided into various groups, some receiving doxorubicin, a drug known for its heart-damaging potential. Others were treated with vitamin D3 or paricalcitol, both thought to have protective qualities against heart injury.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
Read More
8
Vitamin D3 offers cardiac protection
Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress.
Study highlights vitamin D3 benefits.
We examined how vitamin D3 could play a role in protecting the heart from damage caused by cisplatin, a chemotherapy drug. In our research, we worked with male Balb-c mice, dividing them into several groups to evaluate different treatment approaches. Some groups received vitamin D3 before or after cisplatin injection, while others acted as controls.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Read More
7
Vitamin D3's cardiomyoblast protection
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
Explores vitamin D3 and hypertrophy
We explored the effects of vitamin D3, a vital nutrient, on heart health, particularly in relation to a common risk factor known as angiotensin II. Our study focused on H9c2 cardiomyoblasts, a type of heart cell, to understand how vitamin D3 interacts with this condition.
By exposing these cells to angiotensin II along with vitamin D3, we aimed to see if the vitamin could shield the cells from damage. Interestingly, we found that vitamin D3 showed significant potential for preventing cell damage when SIRT1, a protein involved in cell survival, was present. However, when we blocked SIRT1, vitamin D3 wasn’t able to protect the heart cells effectively against the harmful effects induced by angiotensin II.
While vitamin D3 did help mitigate some effects of hypertrophy, or heart cell enlargement, it was clear that SIRT1 was crucial for the vitamin's protective benefits. This finding suggests that enhancing SIRT1 activity could be an exciting path forward for developing treatments to combat heart disease linked to hypertrophy and other conditions related to angiotensin II.
By exposing these cells to angiotensin II along with vitamin D3, we aimed to see if the vitamin could shield the cells from damage. Interestingly, we found that vitamin D3 showed significant potential for preventing cell damage when SIRT1, a protein involved in cell survival, was present. However, when we blocked SIRT1, vitamin D3 wasn’t able to protect the heart cells effectively against the harmful effects induced by angiotensin II.
While vitamin D3 did help mitigate some effects of hypertrophy, or heart cell enlargement, it was clear that SIRT1 was crucial for the vitamin's protective benefits. This finding suggests that enhancing SIRT1 activity could be an exciting path forward for developing treatments to combat heart disease linked to hypertrophy and other conditions related to angiotensin II.
Read More
7
Vitamin D's protective heart role
Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease.
Low relevance to vitamin D3 effects
We delved into how vitamin D, specifically its receptor activation with ligands like calcitriol, influences heart health when glucocorticoids are involved. Our research showed that glucocorticoids, while effective as immunosuppressants, can harm the musculoskeletal and cardiac systems, leading to significant issues such as falls, fractures, and cardiovascular events in long-term users.
Notably, we discovered that glucocorticoids trigger the expression of certain proteins, known as atrogenes, in bones, muscles, and the heart, which promote protein degradation. However, activating the vitamin D receptor helped prevent this negative response in all three tissues. This protective effect was also supported by the use of carfilzomib, which inhibits the proteasome directly.
Additionally, when we looked at genetic changes alongside glucocorticoid treatment, we noted that mice lacking a specific atrogene, MuRF1, experienced less damage in their skeletal and heart muscles. This suggests that targeting the pathway related to MuRF1 may offer a strategy to cushion the adverse impacts of glucocorticoids on these tissues. Ultimately, our findings highlight vitamin D’s potential role in safeguarding heart and muscle health amidst glucocorticoid treatment.
Notably, we discovered that glucocorticoids trigger the expression of certain proteins, known as atrogenes, in bones, muscles, and the heart, which promote protein degradation. However, activating the vitamin D receptor helped prevent this negative response in all three tissues. This protective effect was also supported by the use of carfilzomib, which inhibits the proteasome directly.
Additionally, when we looked at genetic changes alongside glucocorticoid treatment, we noted that mice lacking a specific atrogene, MuRF1, experienced less damage in their skeletal and heart muscles. This suggests that targeting the pathway related to MuRF1 may offer a strategy to cushion the adverse impacts of glucocorticoids on these tissues. Ultimately, our findings highlight vitamin D’s potential role in safeguarding heart and muscle health amidst glucocorticoid treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 42 Reviews
8.7
9.5
Strong immunity support
One capsule a day ensures effective immunity against various viral diseases. My family, including my children, hasn't had a cold or any viral illness for years, aside from a mild runny nose that resolved quickly. With my thyroid condition, vitamin D3 is essential. Its deficiency is linked to heart disease and other autoimmune issues.
Read More
9.5
Eliminated symptoms
Prescribed for my heart disease, this supplement has proven effective. My night sweats and shortness of breath have disappeared, and I experienced no side effects. I may update later with more effects.
9.5
Immunity support
I discovered how vital Vitamin D is through research. It supports bone and heart health, boosts immunity, and prevents illnesses like diabetes and depression. This supplement significantly improves my mood and protection against illness.
9.5
Strengthened immunity
Excellent! We constantly take this vitamin, now in a dosage of 5000 IU. My immunity has improved greatly; previously, we were ill regularly, but now we've gone over a year without even symptoms during colds and flu epidemics. I recommend this vitamin to everyone, as its deficiency is common.
Read More
9.5
Easier Covid recovery
Our family was convinced of vitamin D3's importance after easily overcoming Covid-19. After starting 5000 IU, my levels normalised. We took it with fats for better absorption, and it helped my elderly mother stay healthy despite her conditions.
